Intensified Downstream Processing of Monoclonal Antibodies Using Membrane Technology
نویسندگان
چکیده
منابع مشابه
Application of Membrane Separation Technology in Downstream Processing of Bacillus thuringiensis Biopesticide: A Review
Bacillus thuringiensis (Bt) has been extensively used in biopesticidal formulations due to its safe environmental and human health records. The widespread use of Bt is often challenged by production as well as formulation costs which are in direct contact with downstream processing, i.e. the separation/purification step. Downstream separation/purification efficacy governs the marketabi...
متن کاملMultimodal chromatography: debottlenecking the downstream processing of monoclonal antibodies
2015 The commercial potential of monoclonal antibodies (mAbs) has been continuously increasing during the last years alongside with the number of approved mAb-based drugs and clinical trials. Despite their effectiveness and safety, the general access to this class of biopharmaceuticals is barred by high selling prices. Downstream processing is now considered the bottleneck in the manufacturing ...
متن کاملDownstream Processing of Monoclonal Antibodies: Current Practices and Future Opportunities
s of Papers, 232nd ACS Meeting, San Francisco, CA, 2006. Yigzaw, Y. , Piper, R. , Tran , M. , Shukla , A.A. ( 2006 ). Exploitation of the adsorptive properties of depth filters for host cell protein removal during monoclonal antibody purifi cation. Biotechnology Progress 22, 288–296. Roque, A.C.A. , Silva, C.S.O. , Taipa, M.A. (2007). Affi nit...
متن کاملapplication of membrane separation technology in downstream processing of bacillus thuringiensis biopesticide: a review
bacillus thuringiensis (bt) has been extensively used in biopesticidal formulations due to its safe environmental and human health records. the widespread use of bt is often challenged by production as well as formulation costs which are in direct contact with downstream processing, i.e. the separation/purification step. downstream separation/purification efficacy governs the marketability of a...
متن کاملMonoclonal Antibodies
SUMMARY Monoclonal Antibodies are identical antibodies and Can be generated in ultimated amounts by countinuos cultures of single antibody- secreting cells. These cell lines are produced by cell fusion of normal lymphocytes to cells of a myeloma tumor cell line, which confers on the antibody producing hybrid cell, immortality and the ability grow as atumor in animals. monoclonal antibodies c...
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ژورنال
عنوان ژورنال: Biotechnology Journal
سال: 2020
ISSN: 1860-6768,1860-7314
DOI: 10.1002/biot.202000309